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Resource for Pre-Clinical Studies of AKI
(animal models, small animal imaging and physiology)


Director:
Paul W. Sanders, M.D., Univ of Alabama at Birmingham

Co-Directors:
James George, Ph.D., University of Alabama at Birmingham
Kurt Zinn, Ph.D. University of Alabama at Birmingham
Roland Blantz, M.D., University of California, San Diego

The Resource for Pre-Clinical Studies of AKI (Core B) provides the facilities and requisite skills 1) to study murine models of AKI, 2) for small animal imaging, and 3) to determine renal physiological changes in AKI.

This core specifically provides:

(i) expertise in development and training in the use of rodent models of AKI specifically in the setting of ischemia/reperfusion injury, sepsis and renal transplantation

(ii) a multi-modality small animal imaging core that provides state-of-the-art molecular imaging, including functional, structural and metabolic imaging using magnetic resonance imaging/spectroscopy, high frequency ultrasonography, microCT, gamma-ray imaging (gamma camera, microSPECT/CT, microPET/CT), and optical imaging (bioluminescence and fluorescence)

(iii) a physiology core that provides expertise and training for studying renal function on the whole kidney and at the single nephron level, including micropuncture techniques and determination of GFR, microanalysis of tubular fluid and tubular reabsorption, renal hemodynamics with assessment of tubuloglomerular feedback, and metabolic assessment of kidney oxygen consumption in rodents.

Core B also provides technical expertise for the isolation of primary renal and vascular cells in culture from rodents.


Paul W. Sanders, MD

University of Alabama at Birmingham
Birmingham, AL USA

Kurt Zinn, PhD

University of Alabama at Birmingham
Birmingham, AL USA

Roland Blantz, MD

University of California, San Diego
San Diego, CA USA

James George, PhD

University of Alabama at Birmingham
Birmingham, AL USA

Volker Vallon, MD

University of California, San Diego
San Diego, CA USA